HCID 22884165, compound → HCID 22884140, compound

HRID 1598467Notes

Reaction equation

HRID 1598467 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[C@@H:10]([CH2:21][CH2:22][CH2:23][O:24][CH3:25])[CH2:9]1)C1C=CC=CC=1>[Pd]>[C:17]([O:16][C:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][C@@H:10]1[CH2:21][CH2:22][CH2:23][O:24][CH3:25])=[O:15])([CH3:20])([CH3:19])[CH3:18]

Participants

3

Reactant 1

HCID 22884165HCID 22884165, compound

Product 1

HCID 22884140HCID 22884140, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The title compound was prepared according to the procedure described in Example 2, Step C, except using 4-benzyl-1-tert-butoxycarbonyl-2(S)-(3-methoxy-1-propyl)piperazine (0.870 g, 2.50 mmol) and 10% palladium on carbon (200 mg). The title compound was obtained as an oil (0.450 g). NMR (CDCl3, 300 MHz) δ 4.05 (1H, m), 3.85 (1H, m), 3.40 (2H, m), 3.35 (3H, s), 2.90 (5H, m), 2.70 (1H, dt, J=4, 7 Hz), 1.50-2.0 (4H, m), 1.45 (9H, s).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-e605af436b4245a5bad150e3ed32de18
Source dataset
uspto-grants-1998_04
Patent number
US05736539

Reaction notes

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