HCID 22884166, compound → HCID 67629231, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 2, Step C except using 4-benzyl-1-tert-butoxycarbonyl-2(S)-(4-tert-butoxycarbonylaminobutyl)-piperazine (3.74 g, 8.36 mmol), 10% palladium on carbon (0.50 g) in methanol (50 mL) for 48 h at 60 psi hydrogen. The title compound (Rf 0.3 in 5% methanol in chloroform) was obtained as an oil (3.14 g). NMR (300 MHz, CDCl3) d 4.59 (1H, m), 4.00 (1H, m), 3.83 (1H, br d J=12 Hz), 3.12 (2H, m), 2.90 (4H, m), 2.70 (1H, dt, J=4, 13 Hz), 1.0-1.9 (25H, m).

Provenance & Evidence