Dichloromethane → HCID 22884168, compound

Participants

Reaction Steps

The title compound was obtained according to the procedure described in Example 1, Step E except using methyl 1-(2(R)-tert-butoxycarbonylamino-3-triphenylmethylthiopropyl)-4-(1-naphthylmethyl)-piperazine-2-carboxylate (0.274 g, 0.383 mmol), triethylsilane (0.24 mL, 1.53 mmol) trifluoroacetic acid (5 mL) in dichloromethane (10 mL). The crude product was purified by HPLC by gradient elution (100% Solvent A to 50% Solvent A/50Solvent B over 60 min. After ion exchange, the title compound was obtained as a white solid. FAB ms m/e 374 (m+1).

Provenance & Evidence