Methylhydrazine → HCID 178481741, compound

HRID 1598510Notes

Reaction equation

HRID 1598510 reaction equation
[CH3:1][NH:2][NH2:3].[Cl:4][C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([Cl:15])[C:6]=1[C:16](=O)[CH2:17][C:18]([O:20]CC)=O>C(O)C>[Cl:4][C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([Cl:15])[C:6]=1[C:16]1[CH:17]=[C:18]([OH:20])[N:2]([CH3:1])[N:3]=1

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 18929426Ethyl 3-(2,6-dichloro-4-trifluoromethylphenyl)-3-oxopropionate

Product 1

HCID 178481741HCID 178481741, compoundYield 49.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A solution of 1.0 g of methylhydrazine in 15 ml of ethanol was added dropwise to 6.0 g of ethyl 3-(2,6-dichloro-4-trifluoromethylphenyl)-3-oxopropionate (5) in 50 ml of ethanol at room temperature, and the mixture was thereafter stirred at room temperature for 1 hour and further refluxed overnight. The reaction mixture was concentrated under reduced pressure to obtain a residue, which was washed with hexane to give 2.8 g of the desired compound in the form of white crystals (crude yield 50.0%).

Workup

  1. temperaturefurther refluxed overnight
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customto obtain a residue, which
  4. washwas washed with hexane

Sources & evidence

ORD record
ord-cf85e18857ea44df8b141bc734135e0f
Source dataset
uspto-grants-1998_04
Patent number
US05739083

Reaction notes

Loading…