反应详情

A suspension of 1.0 g of 3-(2,6-dichloro-4-trifluoromethylphenyl)-5-hydroxy-1-methylpyrazole (6) and 0.7 g of Lawesson's reagent in 10 ml of toluene were refluxed with stirring for 3 hours. The solvent was distilled off under reduced pressure, and the resulting residue was purified by column chromatography on silica gel (eluent: ethyl acetate/hexane=1/6), giving 0.3 g of the desired compound in the form of colorless crystals (yield 27.3%).

1. temperaturewere refluxed
2. distillationThe solvent was distilled off under reduced pressure
3. customthe resulting residue was purified by column chromatography on silica gel (eluent: ethyl acetate/hexane=1/6)