Tert-Butyl nitrite → HCID 18929395, compound

Participants

Reaction Steps

First 1.4 g of dimethyl disulfide and then 0.96 g of tert-butyl nitrite were added at 0° C. to a solution of 1.1 g of 5-amino-3-(2,6-dichloro-4-trifluoromethylphenyl)-1-methyl-4-nitropyrazole (14) in 25 ml of anhydrous methylene chloride, and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, the resulting residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate=3/1) to afford 0.6 g of the desired compound in the form of a yellow consistent liquid (yield 60.1%).

Provenance & Evidence