Butyl bromide → HCID 18929402, compound

Participants

Reaction Steps

A solution of 0.8 g of 3-(2,6-dichloro-4-trifluoromethylphenyl)-5-(methylsulfenyl)pyrazole (compound 16), 0.7 g of anhydrous potassium carbonate and 0.4 g of n-butyl bromide in 25 ml of acetone were refluxed for 4 hours. The reaction mixture was filtered through Celite, the filtrate was concentrated under reduced pressure and the resulting residue was purified by column chromatography on silica gel (eluent: ether/hexane=1/20) to obtain 0.3 g of the desired product in the form of a light brown oil (yield 69.6%).

Provenance & Evidence