Bromine → HCID 18929399, compound

HRID 1598525Notes

Reaction equation

HRID 1598525 reaction equation
[Br:1]Br.[NH2:3][C:4]1[CH:8]=[C:7]([C:9]2[C:14]([Cl:15])=[CH:13][C:12]([C:16]([F:19])([F:18])[F:17])=[CH:11][C:10]=2[Cl:20])[N:6]([CH3:21])[N:5]=1>C(Cl)(Cl)(Cl)Cl>[NH2:3][C:4]1[C:8]([Br:1])=[C:7]([C:9]2[C:14]([Cl:15])=[CH:13][C:12]([C:16]([F:19])([F:17])[F:18])=[CH:11][C:10]=2[Cl:20])[N:6]([CH3:21])[N:5]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 18929405HCID 18929405, compound

Product 1

HCID 18929399HCID 18929399, compoundYield 136.9%

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

Bromine (0.12 g) was added to a solution of 0.3 g of 3-amino-5-(2,6-dichloro-4-trifluoromethylphenyl)-1-methylpyrazole in 5 ml of anhydrous carbon tetrachloride at room temperature, and the mixture was stirred at room temperature for 10 minutes. The solvent was distilled off under reduced pressure to obtain a residue, which was then purified by column chromatography on silica gel (eluent: ether/hexane=1/5), affording 0.4 g of the desired compound in the form of white crystals (quantitative yield).

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. customto obtain a residue, which
  3. customwas then purified by column chromatography on silica gel (eluent: ether/hexane=1/5)

Sources & evidence

ORD record
ord-a57a72757c014a90a7c5563a26e9f8b7
Source dataset
uspto-grants-1998_04
Patent number
US05739083

Reaction notes

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