Sodium Hydroxide → HCID 11001505, compound

Participants

Reaction Steps

A mixture of 4-(aminomethyl)-piperidine (1.2 g, 11 mmol), 2-chloro-4-diethylaminoquinazoline (2.5 g, 11 mmol) and Hunig's base (2.8 ml, 16 mmol) in 5 ml of butyronitrile was reacted for 12 hours at 100° C. After cooling, ethyl acetate (50 ml) and 50 ml of sodium hydroxide (10%) were added. The phases were separated and the aqueous phase was extracted with ethyl acetate (2×25 ml). The combined organic phases were dried (Na2SO4), concentrated on a rotary evaporator and purified by chromatography on silica gel (eluent: methylene chloride/ethanol/ammonia, 50/10/1) to give the free base as a thick orange-brown oil.

Provenance & Evidence