Acetic Anhydride → HCID 18929650, compound

Participants

Reaction Steps

A mixture of 2,3-dihydro-7-hydroxy-9-nitro-6-(1-indolinylcarbonyl)-5-oxo-5H-pyrido[1,2,3-de]-1,4-benzoxazine (2.7 g) and acetic anhydride (0.79 g) in pyridine (4 ml) was stirred at room temperature for 1 hour. The mixture was concentrated in vacuo. The residue containing 2,3-dihydro-7-acetoxy-9-nitro-6-(1-indolinylcarbonyl)-5-oxo-5H-pyrido[1,2,3-de]-1,4-benzoxazine was reduced catalytically in a similar manner to that of Example 22 to give crystals of 2,3-dihydro-7-acetoxy-9-amino-6-(1-indolinylcarbonyl)-5-oxo-5H-pyrido[1,2,3-de]-1,4-benzoxazine (1.7 g).

Provenance & Evidence