Potassium Hydroxide → HCID 18929778, compound

HRID 1598579Notes

Reaction equation

HRID 1598579 reaction equation
[N:1]1[NH:2][C:3](=[O:21])[CH2:4][CH2:5][C:6]=1[C:7]1[S:11][C:10]2[CH2:12][CH:13]([NH:16]C(OC)=O)[CH2:14][CH2:15][C:9]=2[CH:8]=1.[OH-].[K+]>CO.O>[N:1]1[NH:2][C:3](=[O:21])[CH2:4][CH2:5][C:6]=1[C:7]1[S:11][C:10]2[CH2:12][CH:13]([NH2:16])[CH2:14][CH2:15][C:9]=2[CH:8]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 18929815HCID 18929815, compound

Product 1

HCID 18929778HCID 18929778, compoundYield 61%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

In 10 ml of methanol was dissolved 1.01 g of 2-[4,5-dihydropyridazin-3(2H)-on-6-yl]-6-methoxycarbonylamino-4,5,6,7-tetrahydrobenzo[b]thiophene, and 560 mg of potassium hydroxide dissolved in 5 ml of water was added thereto. The mixture was stirred at room temperature for 3 hours. Methanol was removed from the reaction mixture, the residue was extracted with ethyl acetate and dried, and the the solvent was removed to obtain 0.5 g of 2-[4,5-dihydropyridazin-3(2H)-on-6-yl]-6-amino-4,5,6,7-tetrahydrobenzo-[b]thiophene as crystals.

Workup

  1. additionwas added
  2. customMethanol was removed from the reaction mixture
  3. extractionthe residue was extracted with ethyl acetate
  4. customdried
  5. customthe the solvent was removed

Sources & evidence

ORD record
ord-46f534f364b04e5e9d22e9f557861d20
Source dataset
uspto-grants-1998_04
Patent number
US05739132

Reaction notes

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