Potassium Carbonate → HCID 18930054, compound

Participants

Reaction Steps

A mixture of methyl 2-(bromomethyl)benzoate (10.00 g, 43.7 mmol), 4-(1-indanyl)phenol (11.47 g, 54.5 mmol), and potassium carbonate (13.27 g, 96.0 mmol) in DMF was heated at 60° C. for 4h, then was allowed to stir at room temperature for 3d. The resulting reaction mixture was partitioned between ether and water, then the organic phase was dried over magnesium sulfate, concentrated, and purified by chromatography over silica gel eluted with 4% ethyl acetate in hexanes to afford 14.8 g of methyl 2-[4-(1-indanyl)phenoxymethyl]benzoate as a colorless oil.

Provenance & Evidence