Ethylene Glycol → HCID 14350178, compound

HRID 1598788Notes

Reaction equation

HRID 1598788 reaction equation
Cl.[N:2]1([C@H:7]2[CH2:12][CH2:11][CH2:10][CH2:9][C@H:8]2[NH:13]C(=O)C2C=CC=CC=2)[CH2:6][CH2:5][CH2:4][CH2:3]1.C(O)CO.[OH-].[K+]>O>[N:2]1([C@H:7]2[CH2:12][CH2:11][CH2:10][CH2:9][C@H:8]2[NH2:13])[CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 174Ethylene GlycolHCID 14797Potassium HydroxideHCID 22844965HCID 22844965, compound

Product 1

HCID 14350178HCID 14350178, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

(±)-cis-2-(1-Pyrrolidinyl)-N-benzoylcyclohexylamine hydrochloride (10 gm) was combined with ethylene glycol (50 ml) and potassium hydroxide (10 gm) and the solution was heated to reflux for 48 hours. The solution was diluted with water (200 ml) and extracted with ether. The ether was removed on a rotary evaporator and the residue was distilled (94° C. at 0.05 mm Hg) to provide the product.

Workup

  1. temperaturethe solution was heated
  2. temperatureto reflux for 48 hours
  3. extractionextracted with ether
  4. customThe ether was removed on a rotary evaporator
  5. distillationthe residue was distilled (94° C. at 0.05 mm Hg)
  6. customto provide the product

Sources & evidence

ORD record
ord-82257b0bdfb444cab728e2e199b0901b
Source dataset
uspto-grants-1998_04
Patent number
US05739158

Reaction notes

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