Trifluoroacetic acid methylene chloride → HCID 70074070, compound

HRID 1598814Notes

Reaction equation

HRID 1598814 reaction equation
[CH3:1][O:2][C:3]1[CH:17]=[C:16]([C@@H:18]2[CH2:20][C@H:19]2[C:21](=[O:41])[C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([N:28]3[CH2:33][CH2:32][N:31](C(OCCCC)=O)[CH2:30][CH2:29]3)[CH:23]=2)[CH:15]=[CH:14][C:4]=1[O:5][CH2:6][C:7]([O:9]C(C)(C)C)=[O:8].C(O)(C(F)(F)F)=O.C(Cl)Cl>>[CH3:1][O:2][C:3]1[CH:17]=[C:16]([C@@H:18]2[CH2:20][C@H:19]2[C:21](=[O:41])[C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([N:28]3[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]3)[CH:23]=2)[CH:15]=[CH:14][C:4]=1[O:5][CH2:6][C:7]([OH:9])=[O:8]

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 131720597HCID 131720597, compound

Product 1

HCID 70074070HCID 70074070, compound

Procedure

Cyclopropyl adduce 300a was deprotected with TFA/CH2Cl2 in the usual way to provide a pale grey solid. IR(KBr): cm-1 3200-2500(br), 1738, 1680. HR-MS: Calc'd 411.1920, Found 411.1925.

Workup

  1. customto provide a pale grey solid

Sources & evidence

ORD record
ord-c910e7ea27104e32a39dadc3448ac44a
Source dataset
uspto-grants-1998_04
Patent number
US05739163

Reaction notes

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