Tetrabutylammonium Fluoride → HCID 18930715, compound

Participants

Reaction Steps

Silyl ether 330d (1.0 g, 1.9 mmol) and tetrabutylammonium fluoride (1M in THF, 1.9 mL, 1.9 mmol) were stirred in THF (40 mL) at room temperature under N2 for 2h. After solvent evaporation, the mixture was extracted with EtOAc and 5% aq. KHSO4, then water, finally brine. Concentration and chromatography on silica gel, eluting with 0% to 40% EtOAc in hexane yielded, after drying, a colorless foam (0.70 g). IR(KBr): cm-1 3334, 1686. MS(NH3): 425 (M+NH4), 402 (M+H).

Provenance & Evidence