4-(Trifluoromethyl)benzoyl chloride → HCID 18930618, compound

HRID 1598909Notes

Reaction equation

HRID 1598909 reaction equation
F[C:2]1[CH:30]=[CH:29][CH:28]=[CH:27][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[NH:12][C:13](=[O:26])[CH2:14][NH:15][C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17])=[O:5].[F:31][C:32]([F:43])([F:42])C1C=CC(C(Cl)=O)=CC=1>>[F:31][C:32]([F:43])([F:42])[C:29]1[CH:30]=[CH:2][C:3]([C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[NH:12][C:13](=[O:26])[CH2:14][NH:15][C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[O:5])=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 676074-(Trifluoromethyl)benzoyl chlorideHCID 18930608HCID 18930608, compound

Product 1

HCID 18930618HCID 18930618, compoundYield 74%

Procedure

According to the method used for synthesis of the compound 28a, the titled compound (592 mg) is synthesized by using tert-butyl((2-trimethylstannylphenyl)-(2-(3-m-tolylureido)acethyl)amino)acetate (1.0 g) and 4-trifluoromethylbenzoylchloride (364 mg). Yield 74%.

Sources & evidence

ORD record
ord-c66b5e77e4194718b4c34f0ac91ea56d
Source dataset
uspto-grants-1998_04
Patent number
US05739162

Reaction notes

Loading…