4-Cyanobenzoyl chloride → HCID 18930612, compound

HRID 1598910Notes

Reaction equation

HRID 1598910 reaction equation
F[C:2]1[CH:30]=[CH:29][CH:28]=[CH:27][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[NH:12][C:13](=[O:26])[CH2:14][NH:15][C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17])=[O:5].[C:31](C1C=CC(C(Cl)=O)=CC=1)#[N:32]>>[C:31]([C:29]1[CH:28]=[CH:27][C:3]([C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[NH:12][C:13](=[O:26])[CH2:14][NH:15][C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[O:5])=[CH:2][CH:30]=1)#[N:32]

Participants

3

Reactant 2

HCID 801724-Cyanobenzoyl chlorideHCID 18930608HCID 18930608, compound

Product 1

HCID 18930612HCID 18930612, compoundYield 76%

Procedure

According to the method used for the synthesis of the compound 28a, the titled compound (551 mg) is synthesized by using tert-butyl((2-trimethylstannylphenyl)-(2-(3-m-tolylureido)acethyl)amino)acetate (1.0 g) and 4-cyanobenzoylchloride (289 mg). Yield 76%.

Sources & evidence

ORD record
ord-bcf02eb2f17d45e09d7ebf384eeb2258
Source dataset
uspto-grants-1998_04
Patent number
US05739162

Reaction notes

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