Formic Acid → N-(3-Hydroxyphenyl)formamide

HRID 1598941Notes

Reaction equation

HRID 1598941 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[CH:9](O)=[O:10]>>[CH:9]([NH:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1)=[O:10]

Participants

3

Reactant 2

HCID 284Formic AcidHCID 115683-Aminophenol

Product 1

HCID 2384379N-(3-Hydroxyphenyl)formamideYield 93.1%

Procedure

A mixture of 100 g m-aminophenol and 150 g formic acid was refluxed for 1.5 h and then evaporated to dryness under reduced pressure (90°-95° C., 10-15 mm Hg). Solid material was dried at 100° C., 10 mm Hg, for 1.5 h. 117 g of the title compound were isolated, melting point 112° C.

Workup

  1. temperaturewas refluxed for 1.5 h
  2. customevaporated to dryness under reduced pressure (90°-95° C., 10-15 mm Hg)
  3. customSolid material was dried at 100° C.

Sources & evidence

ORD record
ord-bc624360872240eab7104b564913aeef
Source dataset
uspto-grants-1998_04
Patent number
US05739318

Reaction notes

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