Lithium Hydroxide → HCID 18931463, compound

Participants

Reaction Steps

To a solution of 8.7 mg (0.02 mmol) of ethyl 4-(2-(4,4-dimethyl-1,2,3,4-tetrahydro-N-phenylquinolin-7-yl)ethynyl)benzoate (Compound 9) in 1.0 mL in tetrahydrofuran was added 0.5 mL (0.1 mmol) of 0.2M aqueous LiOH. The resulting solution was stirred at room temperature for 20 hours. The mixture was then concentrated in vacuo. Water was added, and the mixture was extracted with ethyl acetate (2x). The combined organic layers were washed with brine, dried (MgSO4), filtered, and concentrated in vacuo to give the title compound as a yellow solid. PNMR (300 MHz, DMSO) d 1.31 (6 H, s), 1.81 (2 H, t, J=5.9 Hz), 3.58 (2 H, t, J=5.9 Hz), 6.61 (1 H, s), 6.87 (1 H, d, J=8.0 Hz), 7.19 (1 H, t, J=7.1 Hz), 7.26-7.33(3 H, m), 7.43 (2 H, t, J=7.1 Hz), 7.55 (2 H, d, J=8.2 Hz), 7.89 (2 H, d, J=8.2 Hz).

Provenance & Evidence