HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → Methyl 6-amino-1,3-benzodioxole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1,3-Benzodioxole-5-carboxylic acid, 6-nitro-, methyl ester | HCID 69758 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 6-amino-1,3-benzodioxole-5-carboxylate | HCID 290838 | — |
Reaction Steps
A mixture of the methyl 6-nitro-1,3-benzodioxole-5-carboxylate, 5% palladium on carbon (1.5 g), ethyl acetate (180 mL) and methanol (80 mL) was stirred 3 hours under a hydrogen atmosphere (15 psi). The mixture was filtered and concentrated and the residue was recrystallized from cyclohexane (200 mL) to give methyl 6-amino-1,3-benzodioxole-5-carboxylate (6.3 g, 32 mmol), m.p. 107°-108° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05739336 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-8ccdd3dd60c04b8cbabf949a05640412 |
| Source note | uspto-grants-1998_04 |