反应详情

温度

10 °C

A mixture of methyl 5-iodo-2-methoxybenzoate (14 g, 48 mmol), 30% aqueous sodium hydroxide (40 mL) and methanol (200-300 mL) was allowed to stand approximately 2 hours and th&n heated 5 minutes at reflux. The mixture was concentrated and the residue was stirred with water (500 mL). The mixture was treated with 10% hydrochloric acid (200 mL) and then cooled to 10° C. and the solids were collected and dried under vacuum at 90° C. to give 5-iodo-2-methoxybenzoic acid (13.4 g, 48 mmol), m.p. 150°-152° C.

1. temperatureat reflux
2. concentrationThe mixture was concentrated
3. additionThe mixture was treated with 10% hydrochloric acid (200 mL)
4. customthe solids were collected
5. customdried under vacuum at 90° C.