反应详情

A mixture of 5-iodo-2-methoxybenzoic acid (13.4 g, 48 mmol), acetyl chloride (1 mL) and ethanol (50 mL) was heated 4 hours with stirring at reflux. The mixture was concentrated and the residue was dissolved in diethyl ether. The solution was poured into ice-cold saturated sodium bicarbonate and the organic phase was washed with brine, dried (K2 CO3), filtered and concentrated to give ethyl 5-iodo-2-methoxybenzoate (13.5 g, 44 mmol) as an oil.

1. temperaturewas heated 4 hours
2. temperatureat reflux
3. concentrationThe mixture was concentrated
4. dissolutionthe residue was dissolved in diethyl ether
5. additionThe solution was poured into ice-cold saturated sodium bicarbonate
6. washthe organic phase was washed with brine
7. customdried (K2 CO3)
8. filtrationfiltered
9. concentrationconcentrated