HCID 18931278, compound → HCID 18931134, compound

Participants

Reaction Steps

A mixture of 5-chloro-1-(2,4-dimethoxy-5-nitrophenyl)-1-pentanone (2.9 g, 9.6 mmol), prepared as in Example 12, 10% palladium on carbon (650 mg) and THF (approximately 170 mL) was stirred 3 hours under a hydrogen atmosphere (15 psi). The mixture was filtered and concentrated and the residue was purified by column chromatography eluting with hexane/ethyl acetate (60:40) to give 5-chloro-1-(5-amino-2,4-dimethoxyphenyl)-1-pentanone (1.9 g, 7 mmol), m.p. 87°-88° C.

Provenance & Evidence