4-(Trifluoromethyl)benzenesulfonyl chloride → HCID 18931280, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(5-amino-2,4-dimethoxyphenyl)-5-chloro-1-pentanone (0.54 g, 2 mmol), prepared as in Example 13, 4-trifluoromethylbenzenesulfonyl chloride (0.51 g, 2.1 mmol) triethylamine (0.25 g, 2.5 mmol) and THF (approximately 50 mL) was stirred 16 hours at approximately 25° C. The mixture was concentrated and the residue was partitioned between ethyl acetate and dilute ammonium hydroxide. The organic layer was washed with water (1×) and then brine (1×), dried (K2CO3), filtered and concentrated to give N-[5-(5-chloropentanoyl)-2,4-dimethoxyphenyl]-4-trifluoromethylbenzenesulfonamide (0.8 g, 1.7 mmol), m.p. 150°-153° C.

Provenance & Evidence