HCID 18931130, compound → HCID 18931283, compound

HRID 1598998Notes

Reaction equation

HRID 1598998 reaction equation
C([N:8]1[CH2:22][CH2:21][C:11]2([O:15][C:14](=[O:16])[N:13]([C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:12]2)[CH2:10][CH2:9]1)C1C=CC=CC=1>[Pd].C(O)C>[C:17]([N:13]1[CH2:12][C:11]2([CH2:21][CH2:22][NH:8][CH2:9][CH2:10]2)[O:15][C:14]1=[O:16])([CH3:20])([CH3:18])[CH3:19]

Participants

4

Reactant 1

HCID 18931130HCID 18931130, compound

Product 1

HCID 18931283HCID 18931283, compoundYield 113.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 8-benzyl-3-tert-butyl-3,8-diaza-1-oxaspiro[4.5]decane-2-one (9 g, 30 mmol), 10% palladium on carbon (0.9 g) and ethanol (100 mL) was stirred 6 to 7 hours under a hydrogen atmosphere (50 psi). The mixture was filtered and then concentrated to give crude 3-tert-butyl-3,8-diaza-1-oxaspiro[4.5]decane-2-one (7.2 g), m.p. 108°-111° C.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-52395ce904a24677bc13d6b8bc3d3c8e
Source dataset
uspto-grants-1998_04
Patent number
US05739336

Reaction notes

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