Tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylate → HCID 18931289, compound

HRID 1599003Notes

Reaction equation

HRID 1599003 reaction equation
O[CH:2]([CH2:16][OH:17])[CH2:3][N:4]1[C:8](=[O:9])[C:7]2([CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[NH:6][C:5]1=[O:15].O=C1NC(=O)C2(CCN([C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])CC2)N1>>[O:15]=[C:5]1[N:4]([CH2:3][CH:2]2[O:17][CH2:16]2)[C:8](=[O:9])[C:7]2([CH2:10][CH2:11][N:12]([C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])[CH2:13][CH2:14]2)[NH:6]1

Participants

3

Reactant 2

HCID 3629994Tert-butyl 2,4-dioxo-1,3,8-triazaspiro[4.5]decane-8-carboxylateHCID 18931375HCID 18931375, compound

Product 1

HCID 18931289HCID 18931289, compound

Procedure

3-(2,3-Dihydroxypropyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione may also be prepared by reaction of tert-butyl 2,4-dioxo-1,3,8-triaza-8-spiro[4.5]decanecarboxylate with an epihalohydrin to give tert-butyl 2,4-dioxo-3-(2,3-epoxypropyl)-1,3,8-triaza-8-spiro[4.5]decanecarboxylate, followed by hydrolysis of the epoxy group and deprotection.

Sources & evidence

ORD record
ord-694ec805c10b4e7b8ac28f1cf24568a3
Source dataset
uspto-grants-1998_04
Patent number
US05739336

Reaction notes

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