Potassium Cyanide → HCID 18931291, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-[5-(5-chloro-2-methoxyphenyl)-5,5-ethylenedioxypentyl]-4-piperidone (6.62 g, 18 mmol), potassium cyanide (1.4 g, 35.8 mmol), ammonium chloride (2.46 g, 37 mmol), ammonium hydroxide (14M, 4 mL, 56 mmol), water (25 mL) and methanol (120 mL) was heated 2 hours with stirring at approximately 25° C. and then 5 hours at 60° C. The mixture was concentrated and the residue was dissolved in ethyl acetate. The solution was washed with water (3×) and brine (1×), dried (MgSO4) and concentrated to give 4-amino-1-[5-(5-chloro-2-methoxyphenyl)-5,5-ethylenedioxypentyl]piperidine-4-carbonitrile (5.2 g, 13.1 mmol).

Provenance & Evidence