Sodium hydride → HCID 18931068, compound

Participants

Reaction Steps

A mixture of 4-amino-6-[2-(5-bromopyrimidin-2-yloxy)ethoxy]-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-pyrimidine (100 mg), sodium hydride (60 dispersion, 53.5 mg) and tetrahydrofuran (3 ml) is stirred at room temperature for 20 minutes. To the mixture is added thiophenesulfonyl chloride (23.4 mg), and the mixture is stirred for 22 hours. The reaction solution is treated with a saturated aqueous ammonium chloride solution, and extracted with ethyl acetate. The ethyl acetate layer is washed, dried, and evaporated under reduced pressure to remove the solvent. The residue is purified by preparative thin layer chromatography (solvent; chloroform: methanol=10:1) to give the title compound (49.1 mg).

Provenance & Evidence