反应详情

To a solution of 4,6-dichloro-5-(4-methylphenyl)pyrimidine (4.14 g) in ether (20 ml) is added 27% ammonia in methanol solution (30 ml), and the mixture is reacted at room temperature for three days in a sealed tube. The mixture is evaporated under reduced pressure to remove the solvent, and the residue is purified by silica gel column chromatography (solvent; hexane:ethyl acetate=10:1~ethyl acetate only) to give 4-amino-6-chloro-5-(4-methyl-phenyl)pyrimidine (1.89 g).

1. customthe mixture is reacted at room temperature for three days in a sealed tube
2. customThe mixture is evaporated under reduced pressure
3. customto remove the solvent
4. customthe residue is purified by silica gel column chromatography (solvent