4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine → 2-{[6-Chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]oxy}ethan-1-ol

HRID 1599034Notes

Reaction equation

HRID 1599034 reaction equation
[CH3:1][O:2][C:3]1[CH:23]=[CH:22][CH:21]=[CH:20][C:4]=1[O:5][C:6]1[C:7](Cl)=[N:8][C:9]([C:13]2[N:18]=[CH:17][CH:16]=[CH:15][N:14]=2)=[N:10][C:11]=1[Cl:12]>C(O)CO>[Cl:12][C:11]1[N:10]=[C:9]([C:13]2[N:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[N:8]=[C:7]([O:2][CH2:3][CH2:4][OH:5])[C:6]=1[O:5][C:4]1[CH:20]=[CH:21][CH:22]=[CH:23][C:3]=1[O:2][CH3:1]

Participants

3

Reactant 1

HCID 105457064,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

Product 1

HCID 189310782-{[6-Chloro-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]oxy}ethan-1-ol

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Procedure

5-(2-Methoxyphenoxy)-4,6-dichloro-2-(2-pyrimidinyl)pyrimidine and ethylene glycol are treated in the same manner as in Reference Example 1-(1) to give 2-{6-chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)pyrimidin-4-yloxy}-ethanol (5.37 g) as a powder.

Sources & evidence

ORD record
ord-ff04ba79d9164732a74b5e12e201f94d
Source dataset
uspto-grants-1998_04
Patent number
US05739333

Reaction notes

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