HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 4-Chloro-2-fluoro-5-sulfamoylbenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Chlorosulfonic acid | HCID 24638 | — |
| Reactant | 4-Chloro-2-fluoro-1-(trichloromethyl)benzene | HCID 18931615 | — |
| Product | 4-Chloro-2-fluoro-5-sulfamoylbenzoic acid | HCID 12462572 | — |
Reaction Steps
4-chloro-2-fluoro-benzotrichloride (III) obtained in step (A) is chlorosulfonylated by treatment with sulfuric chlorohydrin in the presence of sulfuric acid and the resulting product is ammonolyzed by treatment with ammonium hydroxide to give 4-chloro-2-fluoro-5-sulfamoyl-benzoic acid (IV);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05739361 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-0e15f147aa2947928872a1644447127e |
| Source note | uspto-grants-1998_04 |