Water → HCID 67660500, compound

Participants

Reaction Conditions

Reaction Steps

76 cm3 of triethylmmine are added to a solution, cooled to +5° C., of 62 g of (R)-5-hydroxymethylcyclohex-2-en-1-one [prepared according to the method described by Kenji Mori et al., Tetrahedron, Vol. 48, No. 24, 8075-8082 (1990) incorporated herein by reference] in 600 cm3 of dry dichloromethane, and then 38.4 cm3 of acetyl chloride are run in over the course of 30 minutes. After stirring at +5° C. for one hour and at 20° C. for one hour, 1 liter of water is added slowly to the mixture. The separated organic phase is washed with 1 liter of water, dried over magnesium sulphate and concentrated to dryness under reduced pressure (2.7 kPa). 80 g of (R)-5-acetoxymetylcyclohex-2-en-1-one are obtained in the form of an orange-coloured oil.

Provenance & Evidence