HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 67661848, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | (2-Benzyloxyphenyl)acetic acid | HCID 519916 | — |
| Reactant | HCID 67660461 | HCID 67660461 | — |
| Catalyst | HCID 178526939 | HCID 178526939 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 67661848 | HCID 67661848 | 55% |
Reaction Steps
The procedure is as described in Example 4, starting from 1.61 g of (3aS,4S,6S,7aR)-6-cyanomethyl-4-(2-methoxyphenyl)perhydroisoindol-4-ol hydrochloride, 50 cm3 of dichloromethane, 0.70 cm3 of triethylamine, 1.21 g of (2-benzyloxyphenyl) acetic acid, 0.02 g of hydroxybenzotriazole hydrate and 1.05 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide. Purification by chromatography followed by recrystallization from ethyl acetate give 1.4 g of (3aS,4S,6S,7aR)-6-cyanomethyl-2-[(2-benzyloxyphenyl)acetyl]-4-(2-methoxyphenyl)perhydroisoindol-4-ol are obtained in the form of white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05739351 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-455698a0cb1d40fab104fc87ddeb81e9 |
| Source note | uspto-grants-1998_04 |