6-Ethoxy-2-methylamino-3-nitropyridine → HCID 10583205, compound

HRID 1599331Notes

Reaction equation

HRID 1599331 reaction equation
[CH2:1]([O:3][C:4]1[N:9]=[C:8]([NH:10][CH3:11])[C:7]([N+:12]([O-])=O)=[CH:6][CH:5]=1)[CH3:2]>O1CCOCC1.[Pd]>[NH2:12][C:7]1[C:8]([NH:10][CH3:11])=[N:9][C:4]([O:3][CH2:1][CH3:2])=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 106317836-Ethoxy-2-methylamino-3-nitropyridine

Product 1

HCID 10583205HCID 10583205, compoundYield 100.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

A procedure similar to that described in Example 6 was repeated, except that 4.95 g of 6-ethoxy-2-methylamino-3-nitropyridine (prepared as described in Preparation 96) were hydrogenated in 100 ml of 1,4-dioxane in the presence of 1.00 g of 10% w/w palladium-on-charcoal. After working up the product as described in Example 6, 4.20 g of the title compound having Rf=0.57 (on silica gel thin layer chromatography using ethyl acetate as the developing solvent) were obtained.

Sources & evidence

ORD record
ord-38564135c4e546fc805f249baa7a3509
Source dataset
uspto-grants-1998_04
Patent number
US05739345

Reaction notes

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