HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 131720619, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | (S)-[(2R,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol | HCID 5953 | — |
| Reactant | Ethyl isocyanatoacetate | HCID 76283 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 131720619 | HCID 131720619 | 46% |
Reaction Steps
To a solution of 200 mg (0.61 mmol) of quinidine in 5 ml of dry dichloromethane was added 74 ml (0.65 mmol) of ethylisocyanatoacetate. The mixture was allowed to stir magnetically at room temperature for 18 h and concentrated under reduced pressure. The residue was purified on preparative thin layer chromatography (silica, 2 mm) using a mixture of 1:9 ethyl acetate:methanol as the eluent and yielded 130 mg (0.28 mmol, 46%) of (8). MS, IR and NMR data confirmed identity of the compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05741715 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-e920f15de8cf43719d7f5647b672e6d4 |
| Source note | uspto-grants-1998_04 |