Sodium Hydroxide → HCID 15837653, compound

HRID 1599383Notes

Reaction equation

HRID 1599383 reaction equation
C([S:4][CH:5]([CH2:26][C:27]1[CH:32]=[CH:31][C:30]([OH:33])=[CH:29][CH:28]=1)[C:6]([NH:8][CH2:9][C:10]([N:12]1[CH:19]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:18][CH2:17][C@H:13]1[C:14]([OH:16])=[O:15])=[O:11])=[O:7])(=O)C.[OH-].[Na+]>CO>[SH:4][CH:5]([CH2:26][C:27]1[CH:28]=[CH:29][C:30]([OH:33])=[CH:31][CH:32]=1)[C:6]([NH:8][CH2:9][C:10]([N:12]1[CH:19]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:18][CH2:17][C@H:13]1[C:14]([OH:16])=[O:15])=[O:11])=[O:7]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15837652HCID 15837652, compound

Product 1

HCID 15837653HCID 15837653, compoundYield 97.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

450 mg of the compound obtained in Example 9 are dissolved in 5 ml of degassed methanol. 2 ml of 1M sodium hydroxide are added at 0° C., and the reaction is continued as described in Example 3. 400 mg of the expected compound are obtained in the form of a white solid.

Sources & evidence

ORD record
ord-4a2bd455f54542c5930e470b3d826054
Source dataset
uspto-grants-1998_04
Patent number
US05741781

Reaction notes

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