HCID 15837667, compound → HCID 15837668, compound

HRID 1599384Notes

Reaction equation

HRID 1599384 reaction equation
[C:1]([S:4][CH:5]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)[C:6]([OH:8])=O)(=[O:3])[CH3:2].[CH3:17][O:18][C:19](=[O:36])[C@@H:20]1[CH2:24][CH2:23][CH:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[OH:31])[N:21]1[C:32](=[O:35])[CH2:33][NH2:34]>CCCCCC.C(OCC)(=O)C>[CH3:17][O:18][C:19](=[O:36])[C@@H:20]1[CH2:24][CH2:23][CH:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[OH:31])[N:21]1[C:32](=[O:35])[CH2:33][NH:34][C:6](=[O:8])[CH:5]([S:4][C:1](=[O:3])[CH3:2])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 15837667HCID 15837667, compoundHCID 15837669HCID 15837669, compound

Product 1

HCID 15837668HCID 15837668, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Condensation of 2-acetylthio-3-(para-chlorophenyl)propanoic acid with N-glycyl-5-(ortho-hydroxyphenyl)proline methyl ester, obtained in accordance with the same protocols as those described in Preparation G, yields the expected product in the form of an oil after chromatography in an n-hexane/ethyl acetate mixture, 1:1.

Workup

  1. customobtained in accordance with the same protocols as
  2. customthose described in Preparation G

Sources & evidence

ORD record
ord-833bbcc865a54359a890fabc37c2f276
Source dataset
uspto-grants-1998_04
Patent number
US05741781

Reaction notes

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