Acetic Acid → HCID 18928128, compound

HRID 1599412Notes

Reaction equation

HRID 1599412 reaction equation
[Br:1][CH2:2][C:3]1[N:7]2[C:8]3[C:13]([N:14]=[C:15](Cl)[C:6]2=[N:5][C:4]=1[C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:12][C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][CH:9]=3.C(O)(=[O:28])C>>[Br:1][CH2:2][C:3]1[N:7]2[C:8]3[C:13]([NH:14][C:15](=[O:28])[C:6]2=[N:5][C:4]=1[C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:12][C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][CH:9]=3

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 18928115HCID 18928115, compound

Product 1

HCID 18928128HCID 18928128, compoundYield 93%

Conditions

Temperature
130 °C

Procedure

A suspension of 1-bromomethyl-4-chloro-2-ethoxycarbonyl-7-trifluoromethylimidazo[1,2-a]quinoxaline (91.0 g, 208 mmol) in glacial acetic acid (750 ml) was heated at 130° C. for 2.5 h. The solvent was removed under reduced pressure and the residue was stirred with ice-cooled water to give 81.2 g (93%) of the title compound. M.p. 247°-248° C.

Workup

  1. customThe solvent was removed under reduced pressure
  2. temperaturecooled water

Sources & evidence

ORD record
ord-fb01d52efe7b4cd59dfa2c09928091f4
Source dataset
uspto-grants-1998_04
Patent number
US05741785

Reaction notes

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