Potassium Carbonate → 1-(4,5-Dichloro-1-imidazolyl)methyl-2-ethoxycarbonyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one

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Reaction Conditions

Reaction Steps

A suspension of 1-bromomethyl-2-ethoxycarbonyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one (Example 3) (2.1 g, 5.0 mmol), 4,5-dichloroimidazole (1.5 g, 11.0 mmol) and potassium carbonate (1.5 g, 11 mmol) in acetonitril (100 ml) was stirred at 80° C. for 5 h and overnight at room temperature. The solvent was evaporated in vacuo and the residue submitted to flash chromatography on silica gel 60 eluting with dichloromethane/methanole (19:1) to give 540 mg (23%) of the title compound. M.p. 240° C.

Provenance & Evidence