Water → HCID 86752432, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-formyl-1-(1-imidazolylmethyl)-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one (250 mg, 0.69 mmol) in methanol (10 ml) was added a mixture of hydroxylammonium chloride (65 mg, 0.95 mmol) and sodiumacetate (150 mg, 1.10 mmol) in methanol (10 ml). The reaction mixture was heated at 70° C. for 1.5 h, followed by addition of water (10 ml). The precipitate was filtered off and washed with water. Recrystalization from isopropanol/petroleum ether gave 150 mg (58%) of the title compound. M.p. 227.5°-228° C.

Provenance & Evidence