反应详情

A solution of 4-ethoxycarbonyl-5-methyl-1-(2-nitro-5-(1-imidazolyl)phenyl)-1H-imidazole (14 g, 41 mmol) in ethanol (1.0 l) was hydrogenated in a PARR hydrogenation apparatus at 30 psi and 25° C. using 1.0 g 5% Pd-C as a catalyst. The reaction mixture was filtered and concentrated in vacuo to give 12.4 g (98%) of 1-(2-amino-5-(1-imidazolyl)phenyl)-4-ethoxycarbonyl-5-methyl-1H-imidazole.

1. customwas hydrogenated in a PARR hydrogenation apparatus at 30 psi and 25° C.
2. filtrationThe reaction mixture was filtered
3. concentrationconcentrated in vacuo