Triethyl phosphite → 2-Ethoxycarbonyl-1-diethoxyphosphoryl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one

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Reaction Steps

1-Bromomethyl-2-ethoxycarbonyl-7-trifluoromethylimidazo[1,2-a]quinoxalin-4(5H)-one (Example 3) (840 mg, 2.0 mmol) and triethyl phosphite (12 ml) was heated at 120° C. for 16 h. The mixture was concentrated in vacuo and the residue submitted to flash chromatography on silica gel, eluting with dichloromethane/methanol (9:1). The purified product was washed with ether to give 600 mg (63%) of the title compound. M.p. 198°-199° C.

Provenance & Evidence