Acetonitrile → Morpholin-4-ylsulfamyl chloride

HRID 1599439Notes

Reaction equation

HRID 1599439 reaction equation
[S:1]([Cl:5])(Cl)(=[O:3])=[O:2].[NH:6]1[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1.C(#[N:14])C>>[O:9]1[CH2:10][CH2:11][N:6]([NH:14][S:1]([Cl:5])(=[O:3])=[O:2])[CH2:7][CH2:8]1

Participants

4

Reactant 3

HCID 6342Acetonitrile2×HCID 8083MorpholineHCID 24648Sulfuryl chloride

Product 1

HCID 13271200Morpholin-4-ylsulfamyl chloride

Procedure

To a solution of sulphuryl chloride (27.7 ml, 3mol equiv) in acetonitrile (25 ml) under nitrogen was added a solution of morpholine (10 g, 114 mmol) in acetonitrile (25 ml). The reaction was heated under reflux for 15 hours, then cooled to room temperature and concentrated in vacuo to give the title compound (20.45 g).

Workup

  1. temperatureThe reaction was heated
  2. temperatureunder reflux for 15 hours
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-5d7080eb23534041a5cab40b26609ba0
Source dataset
uspto-grants-1998_04
Patent number
US05741790

Reaction notes

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