HCID 53754201, compound → Ethyl 6-amino-1H-benzimidazole-2-acetate

HRID 1599468Notes

Reaction equation

HRID 1599468 reaction equation
[N+:1]([C:4]1[CH:18]=[CH:17][C:7]2[N:8]=[C:9]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[NH:10][C:6]=2[CH:5]=1)([O-])=O>[Pd].C(O)C>[NH2:1][C:4]1[CH:18]=[CH:17][C:7]2[N:8]=[C:9]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[NH:10][C:6]=2[CH:5]=1

Participants

4

Reactant 1

HCID 53754201HCID 53754201, compound

Product 1

HCID 54171359Ethyl 6-amino-1H-benzimidazole-2-acetate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of ethyl 5-nitrobenzimidazole-2-acetate (206 mg, 0.83 mmol, 1 equiv.), 10% palladium on carbon (88 mg, 0.08 mmol, 0.1 equiv.), and absolute ethanol (8 mL) was stirred at room temperature under hydrogen (balloon). After 45 minutes, the reaction was filtered through Celite®, and the filtrate was concentrated to afford crude ethyl 5-aminobenzimidazole-2-acetate. This was used without further purification.

Workup

  1. filtrationthe reaction was filtered through Celite®
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-943e802d0a5a4a16a2ed835d1e0a965d
Source dataset
uspto-grants-1998_04
Patent number
US05741804

Reaction notes

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