Thionyl Chloride → HCID 18928715, compound

Participants

Reaction Conditions

Reaction Steps

A solution of thionyl chloride (15.7 ml) in dry chloroform (100 ml) was added dropwise to a stirred solution of the product from Example 35 (51.1 g) in dry chloroform (500 ml) over 45 minutes, keeping the temperature between 0° C. and 5° C. The solution was allowed to warm to 20° C. with stirring and then heated under reflux for 2.5 hours. The mixture was cooled to 20° C., washed (saturated sodium bicarbonate solution, water), dried, filtered and evaporated to give 4-(2-chloroethyl)-1-(3-phenylpropionyl)piperidine as oil.

Provenance & Evidence