Dimethylformamide → HCID 15838025, compound

Participants

Reaction Conditions

Reaction Steps

Dimethyl formamide (DMF) (8 ml) was stirred at 0° C. for 10 minutes, POCl3 (1 ml) was added and then stirred for 1 hours. 5-Heptyl-2,2'-bithiophene (0.5 g) dissolved in dimethyl formamide (5 ml) was added and stirred at room temperature for half an hour at room temperature, then the temperature was raised to 60° C. and was further stirred for 4 hours. The reaction solution was then extracted with dichloromethane, neutralized with sodium acetate, washed with water to neutrality, dried, concentrated and separated by silica gel chromatography eluted with ethyl acetate/n-hexane (1/15). Light yellowish oily product (0.86 g, 86%) was obtained.

Provenance & Evidence