Sodium borohydride → HCID 10063895, compound

HRID 1599515Notes

Reaction equation

HRID 1599515 reaction equation
[CH:1]([C:3]1[S:7][C:6]([C:8]2[S:9][C:10]([C:13]3[S:14][CH:15]=[C:16]([CH2:18][OH:19])[CH:17]=3)=[CH:11][CH:12]=2)=[CH:5][CH:4]=1)=[O:2].[BH4-].[Na+]>CO>[OH:2][CH2:1][C:3]1[S:7][C:6]([C:8]2[S:9][C:10]([C:13]3[S:14][CH:15]=[C:16]([CH2:18][OH:19])[CH:17]=3)=[CH:11][CH:12]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 10040825HCID 10040825, compound

Product 1

HCID 10063895HCID 10063895, compoundYield 99.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 5-formyl-4"-hydroxymethyl-2,2':5', 2"-terthiophene (140 mg) in methanol (10 ml) was added sodium borohydride (0.1 g). The reaction mixture was stirred at room temperature for 40 minutes. Methanol was removed and water was added. The solution was extracted with ethyl acetate, washed with brine, dried over anhydrous magnesium sulfate and concentrated to give light yellowish solid product (140 mg), melting point 111°-113° C.

Workup

  1. customMethanol was removed
  2. additionwater was added
  3. extractionThe solution was extracted with ethyl acetate
  4. washwashed with brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-8b1a81f5c8494f3e91f6afcf116c0006
Source dataset
uspto-grants-1998_04
Patent number
US05741811

Reaction notes

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