Halothane → 3-(1-Methylpyrrolidin-2-yl)pyridine

HRID 1599652Notes

Reaction equation

HRID 1599652 reaction equation
C(C(F)(F)F)(Br)Cl.C(C(C(C(O)=O)O)O)(O)=O.C(C(C(C(O)=O)O)O)(O)=O.[N:28]1[CH:33]=[C:32]([CH:34]2[CH2:39][CH2:38][CH2:37][N:35]2[CH3:36])[CH:31]=[CH:30][CH:29]=1>>[N:28]1[CH:33]=[C:32]([CH:34]2[CH2:39][CH2:38][CH2:37][N:35]2[CH3:36])[CH:31]=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 3562Halothane2×HCID 10434468HCID 10434468, compound2×

Product 1

HCID 9423-(1-Methylpyrrolidin-2-yl)pyridine

Procedure

Rats were anesthetized with halothane and Alzet osmotic minipumps (Alza Corporation, Palo Alto, Calif., Model 2ML2) were implanted subcutaneously. Nicotine ditartrate was dissolved in physiological saline. Pumps were filled with either nicotine ditartrate (6 mg/kg base/day) or physiological saline. Twelve days following implantation of pumps, rats were anesthetized with halothane and the pumps were removed.

Workup

  1. customTwelve days
  2. customthe pumps were removed

Sources & evidence

ORD record
ord-50f61b29ab9448d298eba7ff1e82466c
Source dataset
uspto-grants-1998_04
Patent number
US05741789

Reaction notes

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