反应详情

温度

40 °C

Tetrazolo[1,5-a]quinolin-5-ol (10 g, 54 mmole, Example 1)was suspended in acetic acid (200 mL) then warmed to 40° C. Nitric acid (4 mL of 16M, 59 mmole) was added to the reaction mixture. The reaction mixture was heated at 80° C. for 30 minutes then allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, rinsed with water then recrystallized from isopropanol/water to provide 8.1 g of 4-nitrotetrazolo[1,5-a]quinolin-5-ol hydrate as light yellow plates, m.p. 186.5°-187° C. Analysis: Calculated for C9H5 N5O3.H2O: % C, 43.38; % H, 2.83; % N, 28.10; Found: % C, 43.27; % H, 2.84; % N, 28.25.

1. temperatureThe reaction mixture was heated at 80° C. for 30 minutes
2. temperatureto cool to ambient temperature
3. customThe resulting precipitate was isolated by filtration
4. washrinsed with water
5. customthen recrystallized from isopropanol/water