Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Toluenesulfonic acid monohydrate → 4-Methoxycarbonyl-4-phenylpiperidine p-toluenesulfonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 반응물 | 4-Piperidinecarboxylic acid, 4-phenyl-, 4-methylbenzenesulfonate (1:1) | HCID 2723657 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-Methoxycarbonyl-4-phenylpiperidine p-toluenesulfonate | HCID 21699518 | 453.8% |
반응 단계
1 g of para-toluenesulfonic acid monohydrate is added to a solution of 10 g of 4-carboxy-4-phenylpiperidine p-toluenesulfonate in 300 ml of MeOH and the mixture is refluxed for 3 days. The reaction mixture is concentrated under vacuum, the residue taken up in acetone and ether is added until precipitation occurs. After spinning the precipitate formed, 9.34 g of the expected product are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05741910 |
| 출처 데이터셋 | uspto-grants-1998_04 |
| ORD ID | ord-550146f2dfca43b09824f83af158d1fb |
| 출처 메모 | uspto-grants-1998_04 |